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ZNF581 and EFEMP2
Data Source:
BioGRID
(two hybrid)
ZNF581
EFEMP2
Description
zinc finger protein 581
EGF containing fibulin extracellular matrix protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Microfibril
Extracellular Region
Basement Membrane
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Exosome
Elastic Fiber
Extracellular Vesicle
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Protein Homodimerization Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Aorta Development
Elastic Fiber Assembly
Aorta Smooth Muscle Tissue Morphogenesis
Vascular Associated Smooth Muscle Cell Development
Regulation Of Collagen Fibril Organization
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Diseases
Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS
Acne (severe) (
24927181
)
Adult body size (
32376654
)
Birth weight (
31043758
)
Body size at age 10 (
32376654
)
Retinal detachment or retinal break (
31816047
)
Interacting Genes
95 interacting genes:
AP2M1
APOBEC3C
APP
ASB13
ATG9A
BANP
BOLA2
BOLA2B
CALCOCO2
CARD10
CBY2
CCDC136
CCNDBP1
CHURC1
CNFN
CYSRT1
DAZAP2
DOCK8
DVL2
DVL3
EFEMP2
ENKD1
ETFDH
FAM90A1
FANCL
FHL5
FSD2
GOLGA2
GOLGA6L9
GOPC
GPSM3
HMBOX1
HNRNPC
HNRNPF
HSF2BP
IKZF1
IL16
KDM1A
KHDRBS2
KRT27
KRT34
KRT40
KRTAP1-1
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP2-3
KRTAP2-4
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP6-2
LNX1
LNX2
LZTS2
MDFI
MGAT5B
MTUS2
NBPF19
NID2
NOTCH2NLA
NUDT22
PDE4DIP
PLAGL2
PLEKHF2
PLSCR1
PNMA1
POU2AF1
PRKAB2
RBPMS
RIMBP3C
RSKR
SDCBP2
SERTAD2
SMARCC1
SOX5
SPAG8
SPG21
SUV39H1
TEKT4
TMCC2
TRAF1
TRAF4
TRIM23
TRIM27
TRIM55
TRIM63
TRIP6
WWOX
ZNF765
ZNF792
ZRANB1
130 interacting genes:
ADAMTSL4
AMMECR1
ANAPC11
AP1M1
APEX2
AQP1
ARRDC3
ATN1
ATXN1
ATXN7
BAG6
C3
C5orf24
CACNA1A
CATSPER1
CCDC33
CCND3
CCNK
CDPF1
CLPP
CNNM3
COL8A1
CREB5
CXCL5
CYSRT1
DGCR6
DOK7
FAM107A
FAM110A
FAM124B
FAM74A4
FAM90A1
FBXW5
FTO
GFI1B
GLRX3
HDAC4
HHEX
HHIPL1
HOXA1
HPCAL1
HSD3B7
HSPA12B
HSPBP1
IGFBP6
IL16
INCA1
ITGB5
KLF1
KRTAP10-8
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-5
KRTAP26-1
KRTAP3-2
LBX1
LCE1A
LCE1C
LCE1E
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE3E
LINGO1
LNX1
MDFI
MEOX2
MRPL12
MXI1
NEDD4L
NOS3
NR1D2
NTM
NUFIP2
OTX1
P2RX7
PIDD1
PITX1
PLSCR1
PLSCR4
PROP1
PRPF31
PRR32
PTGER3
RAB40B
RBAK
RBP3
RBPMS
RERE
RHOXF2
RHPN1
RIBC2
RNF138
SGTA
SGTB
SLC16A5
SLC23A1
SLC25A48
SPACA9
SPATA24
SPATA3
SPATA8
SPRY4
STK16
TCAF1
THAP7
TLE5
TLX3
TP53
TRIB3
TRIM42
UBQLN1
UBQLN4
USP21
ZNF263
ZNF345
ZNF426
ZNF558
ZNF57
ZNF581
ZNF587
ZNF638
ZNF670
ZNF699
ZNF768
ZNF774
ZNF837
Entrez ID
51545
30008
HPRD ID
15858
05221
Ensembl ID
ENSG00000171425
ENSG00000172638
Uniprot IDs
Q9P0T4
A0A024R5G1
O95967
Q9H3D5
PDB IDs
2KL7
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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