ANAPC11 and OXER1

Data Source:
BioGRID (two hybrid)

		ANAPC11	OXER1
Description		anaphase promoting complex subunit 11	oxoeicosanoid receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Nucleolus Cytosol Cullin-RING Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity Cullin Family Protein Binding	G Protein-coupled Receptor Activity Protein Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding
	Biological Process	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Eicosanoid ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18821565) Breastfeeding duration ( 25475840) Hyperactive-impulsive symptoms ( 18821565)
Interacting Genes		55 interacting genes: ANAPC10 ANAPC2 ANAPC4 BANP BEND2 CAPN11 CCNB1 CDC16 CDC20 CREB5 CRYBA2 CUL5 CYSRT1 DTX2 EFEMP1 EFEMP2 FBXO5 FRS3 FZR1 GPANK1 HSD3B7 IQUB KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP3-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 MAK MGAT5B MLKL NKD2 OXER1 P4HA3 PRKAA2 PRKAB2 PTTG1 RBPMS RNF111 TCEANC TEX37 TLE5 TRIM65 UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2K UBE2L1 UBE2S UBE2U WWOX ZAP70	46 interacting genes: ANAPC11 ARRB2 ASB13 ATG9A CCNK CRYBA2 EFCAB3 ESRP1 FOXH1 HNF1B HNRNPH1 INTS11 JMJD7 KRTAP12-3 KRTAP19-5 KRTAP4-2 KRTAP5-6 KRTAP6-3 LASP1 MED25 NCS1 NEK8 NOC4L OTX1 PLSCR4 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 RAMAC RBFOX2 RECK RNF208 RNF38 RNF44 TFG TLE5 TP53BP1 VGLL3 ZBTB32 ZC3H10 ZIC1
Entrez ID		51529	165140
HPRD ID		12452	17812
Ensembl ID		ENSG00000141552	ENSG00000162881
Uniprot IDs		A0A024R8S1 Q9NYG5	Q8TDS5
PDB IDs		2MT5 4R2Y 4UI9 5A31 5G04 5G05 5JG6 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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