DTL and POLD4

Data Source:
BioGRID (enzymatic study)

		DTL	POLD4
Description		denticleless E3 ubiquitin protein ligase homolog	DNA polymerase delta 4, accessory subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Centrosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex	Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Cell Cycle Signal Transduction Involved In G2 DNA Damage Checkpoint	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage
Pathways		Recognition of DNA damage by PCNA-containing replication complex Neddylation	Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 RBX1 TDG TOB1 TP53 UBE2D1 UBE2N	9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		51514	57804
HPRD ID		17952	17873
Ensembl ID		ENSG00000143476	ENSG00000175482
Uniprot IDs		B4E0E6 Q9NZJ0	A0A024R5D7 Q6NSD7 Q9HCU8
PDB IDs		6QC0	6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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