HIKESHI and OTX2

Data Source:
BioGRID (two hybrid)

		HIKESHI	OTX2
Description		heat shock protein nuclear import factor hikeshi	orthodenticle homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck	Chromatin Nucleus Growth Cone Protein-containing Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding Nuclear Import Signal Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Import Into Nucleus Golgi Organization Protein Transport Lung Development Cellular Response To Heat Regulation Of Cellular Response To Heat	Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation
Pathways		Regulation of HSF1-mediated heat shock response
Drugs
Diseases			Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS			Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ABLIM3 APP OTX2	43 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1
Entrez ID		51501	5015
HPRD ID		13701	07190
Ensembl ID		ENSG00000149196	ENSG00000165588
Uniprot IDs		Q53FT3	F1T0C9 F1T0D0 F1T0D1 P32243
PDB IDs		3WVZ 3WW0
Enriched GO Terms of Interacting Partners?
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