TRIAP1 and AMY2A

Data Source:
BioGRID (two hybrid)

		TRIAP1	AMY2A
Description		TP53 regulated inhibitor of apoptosis 1	amylase alpha 2A
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Intermembrane Space Protein-containing Complex	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	P53 Binding Protein Binding Phosphatidic Acid Transfer Activity	Alpha-amylase Activity Calcium Ion Binding Chloride Ion Binding Alpha-amylase Activity (releasing Maltohexaose)
	Biological Process	Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Phospholipid Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To UV Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Membrane Lipid Distribution Intermembrane Lipid Transfer Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Phospholipid Transport	Carbohydrate Metabolic Process Carbohydrate Catabolic Process Polysaccharide Digestion
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	Digestion of dietary carbohydrate
Drugs			Acarbose Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam N-[4-hydroxymethyl-cyclohexan-6-yl-1,2,3-triol]-4,6-dideoxy-4-aminoglucopyranoside Beta-D-Glucose 4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose Pidolic acid 5-Hydroxymethyl-Chonduritol 4,6-dideoxy-4-amino-alpha-D-glucose 6)-Alpha-L-Threo-Hexopyranose alpha-D-quinovopyranose Acarbose Derived Hexasaccharide 4-O-(4,6-Dideoxy-4-{[4-[(4-O-Hexopyranosylhexopyranosyl)Oxy]-5,6-Dihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}Hexopyranosyl)Hexopyranose 4)HEXOPYRANOSE
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Insulin resistance/response ( 21901158) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		6 interacting genes: AMY2A APAF1 HSPA1A LCN2 PLEKHF2 TP53	3 interacting genes: GP2 IGF1R TRIAP1
Entrez ID		51499	279
HPRD ID		13698	00094
Ensembl ID		ENSG00000170855	ENSG00000243480
Uniprot IDs		O43715	P04746 Q53F26
PDB IDs		4XZS 4XZV 6I3V 6I3Y 6I4Y	1B2Y 1BSI 1CPU 1HNY 1KB3 1KBB 1KBK 1KGU 1KGW 1KGX 1U2Y 1U30 1U33 1XCW 1XCX 1XD0 1XD1 1XGZ 1XH0 1XH1 1XH2 2CPU 2QMK 2QV4 3BAI 3BAJ 3BAK 3BAW 3BAX 3BAY 3CPU 3IJ7 3IJ8 3IJ9 3OLD 3OLE 3OLG 3OLI 4GQQ 4GQR 4W93 4X9Y 5E0F 5EMY 5KEZ 5TD4 5U3A 5VA9 6OBX 6OCN
Enriched GO Terms of Interacting Partners?
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