EVL and GSKIP

Data Source:
BioGRID (affinity chromatography technology)

		EVL	GSKIP
Description		Enah/Vasp-like	GSK3B interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Protein Kinase Inhibitor Activity Protein Binding Beta-catenin Binding Kinase Regulator Activity Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Negative Regulation Of Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Conotruncal heart defects (inherited effects) ( 28468790)
Interacting Genes		33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX	3 interacting genes: EXT2 GSK3A PEX19
Entrez ID		51466	51527
HPRD ID		10942	16601
Ensembl ID		ENSG00000196405	ENSG00000100744
Uniprot IDs		A0A024R6K5 Q9UI08	A0A024R6P6 Q9P0R6
PDB IDs			1SGO
Enriched GO Terms of Interacting Partners?
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