MBTPS2 and ATF6B

Data Source:
HPRD (in vivo)

		MBTPS2	ATF6B
Description		membrane bound transcription factor peptidase, site 2	activating transcription factor 6 beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane	Chromatin Nucleus Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Metalloendopeptidase Activity Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-binding Transcription Factor Activity Bone Maturation Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Regulation Of Transcription By RNA Polymerase II Signal Transduction Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones CREB3 factors activate genes CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases		Ichthyosis follicularis, alopecia, and photophobia syndrome Keratosis follicularis spinulosa decalvans
GWAS			Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 32469254) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908)
Interacting Genes		1 interacting genes: ATF6B	10 interacting genes: ATF6 CDK6 CREBZF LHX8 MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1
Entrez ID		51360	1388
HPRD ID		02243	02992
Ensembl ID		ENSG00000012174	ENSG00000213676
Uniprot IDs		O43462	A0A1U9X796 Q6AZW6 Q99941
PDB IDs
Enriched GO Terms of Interacting Partners?
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