ATF6B and MBTPS2

Data Source:
HPRD (in vivo)

		ATF6B	MBTPS2
Description		activating transcription factor 6 beta	membrane bound transcription factor peptidase, site 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Sequence-specific Double-stranded DNA Binding	Metalloendopeptidase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Signal Transduction Endoplasmic Reticulum Unfolded Protein Response ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-binding Transcription Factor Activity Bone Maturation Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) ATF6 (ATF6-alpha) activates chaperones CREB3 factors activate genes CREB3 factors activate genes Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases			Ichthyosis follicularis, alopecia, and photophobia syndrome Keratosis follicularis spinulosa decalvans
GWAS		Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 32469254) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: ATF6 CDK6 CREBZF LHX8 MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1	1 interacting genes: ATF6B
Entrez ID		1388	51360
HPRD ID		02992	02243
Ensembl ID		ENSG00000213676	ENSG00000012174
Uniprot IDs		A0A1U9X796 Q6AZW6 Q99941	O43462
PDB IDs
Enriched GO Terms of Interacting Partners?
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