TNFRSF12A and TNFSF12

Data Source:
HPRD (in vivo)

		TNFRSF12A	TNFSF12
Description		TNF receptor superfamily member 12A	TNF superfamily member 12
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Apoptotic Process Cell Adhesion Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Wound Healing Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 29875488) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Emotional recognition ( 31596458) HDL cholesterol levels ( 32203549) Myopia ( 27182965) Plateletcrit ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		8 interacting genes: KRTAP3-3 RAC1 SLC30A2 TNFSF12 TRAF1 TRAF2 TRAF3 TRAF5	6 interacting genes: AGGF1 DDIT3 LMNA SGTA TNFRSF12A TNFRSF25
Entrez ID		51330	8742
HPRD ID		05801	04074
Ensembl ID		ENSG00000006327	ENSG00000239697
Uniprot IDs		Q9NP84	O43508 Q4ACW9
PDB IDs		2EQP 2KMZ 2RPJ	4HT1
Enriched GO Terms of Interacting Partners?
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