NME8 and RIPK3

Data Source:
BioGRID (pull down)

		NME8	RIPK3
Description		NME/NM23 family member 8	receptor interacting serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Axoneme Nuclear Speck Outer Dynein Arm Sperm Midpiece Sperm Principal Piece Sperm Cytoplasmic Droplet	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Microtubule Binding	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein-containing Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Multicellular Organism Development Spermatogenesis Cell Differentiation Flagellated Sperm Motility Cellular Response To Reactive Oxygen Species Cilium Assembly	Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Cellular Protein Modification Process Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatase Activity Activation Of Protein Kinase Activity Regulation Of Interferon-gamma Production T Cell Differentiation In Thymus NIK/NF-kappaB Signaling Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Transcription, DNA-templated Regulation Of Activated T Cell Proliferation Protein Autophosphorylation Lymph Node Development Spleen Development Thymus Development Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ligase Activity Positive Regulation Of Oxidoreductase Activity Defense Response To Virus Positive Regulation Of Necroptotic Process Regulation Of Activation-induced Cell Death Of T Cells Necroptotic Process Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Necroptotic Signaling Pathway Execution Phase Of Necroptosis Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Periodontitis ( 25672891)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		2 interacting genes: APP RIPK3	22 interacting genes: BIRC2 BIRC3 BUB1B DAXX GBE1 H1-5 HELQ HSPBAP1 IL24 NME8 PELI1 RFX6 RIPK1 SRPK2 TICAM1 TLE6 TMEM44 TNFRSF1A TRAF2 UTP11 XIAP ZSCAN20
Entrez ID		51314	11035
HPRD ID		16243	09315
Ensembl ID		ENSG00000086288	ENSG00000129465
Uniprot IDs		Q8N427	Q9Y572
PDB IDs			5V7Z 5ZCK
Enriched GO Terms of Interacting Partners?
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