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RIPK3 and HELQ
Data Source:
BioGRID
(pull down)
RIPK3
HELQ
Description
receptor interacting serine/threonine kinase 3
helicase, POLQ like
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Protein-containing Complex
Nucleus
Molecular Function
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein-containing Complex Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
DNA Binding
Protein Binding
ATP Binding
Single-stranded 3'-5' DNA Helicase Activity
Biological Process
Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Adaptive Immune Response
Cellular Protein Modification Process
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Phosphatase Activity
Activation Of Protein Kinase Activity
Regulation Of Interferon-gamma Production
T Cell Differentiation In Thymus
NIK/NF-kappaB Signaling
Regulation Of Apoptotic Process
T Cell Homeostasis
Positive Regulation Of Transcription, DNA-templated
Regulation Of Activated T Cell Proliferation
Protein Autophosphorylation
Lymph Node Development
Spleen Development
Thymus Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Oxidoreductase Activity
Defense Response To Virus
Positive Regulation Of Necroptotic Process
Regulation Of Activation-induced Cell Death Of T Cells
Necroptotic Process
Cellular Response To Hydrogen Peroxide
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Necroptotic Signaling Pathway
Execution Phase Of Necroptosis
Amyloid Fibril Formation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Double-strand Break Repair Via Homologous Recombination
RRNA Processing
DNA Duplex Unwinding
Pathways
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
TLR3-mediated TICAM1-dependent programmed cell death
IKK complex recruitment mediated by RIP1
Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Diastolic blood pressure (
27841878
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Age-related cognitive decline (executive function) (slope of z-scores) (
30954325
)
Breast cancer (
29059683
)
Menopause (age at onset) (
22267201
26414677
29773799
)
Interacting Genes
22 interacting genes:
BIRC2
BIRC3
BUB1B
DAXX
GBE1
H1-5
HELQ
HSPBAP1
IL24
NME8
PELI1
RFX6
RIPK1
SRPK2
TICAM1
TLE6
TMEM44
TNFRSF1A
TRAF2
UTP11
XIAP
ZSCAN20
1 interacting genes:
RIPK3
Entrez ID
11035
113510
HPRD ID
09315
08422
Ensembl ID
ENSG00000129465
ENSG00000163312
Uniprot IDs
Q9Y572
Q8TDG4
PDB IDs
5V7Z
5ZCK
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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