PLCE1 and GHITM

Data Source:
BioGRID (imaging technique)

		PLCE1	GHITM
Description		phospholipase C epsilon 1	growth hormone inducible transmembrane protein
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Lamellipodium	Mitochondrion Integral Component Of Mitochondrial Inner Membrane Extracellular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Enzyme Binding Small GTPase Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cell Growth Diacylglycerol Biosynthetic Process Regulation Of Smooth Muscle Contraction Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Ras Protein Signal Transduction Heart Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Inositol Phosphate Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Ras Protein Signal Transduction Phosphatidylinositol-mediated Signaling Inositol Phosphate-mediated Signaling	Apoptotic Process Inner Mitochondrial Membrane Organization Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Birth weight ( 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 29212778) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 27841878 21909115 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glucose homeostasis traits ( 25524916) Hypertension ( 31879980 21909115) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Migraine ( 27182965 27322543) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Optic cup area ( 31798171) Personality traits in bipolar disorder ( 21368711) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Platelet reactivity in response to clopidogrel treatment ( 32472697) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 28739976 30578418) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 27841878 21909115 28739976 27618452 30578418) Vertical cup-disc ratio ( 31798171 25241763) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)	Abstraction and mental flexibility ( 31596458) Influenza A (H1N1) infection ( 26379185) Metabolite levels ( 23823483) Mild influenza (H1N1) infection ( 26379185) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: HRAS KIT LIMS1 NRAS PPP1R3B	13 interacting genes: AGTR1 CCR4 DRD2 FAM209A FXYD3 GPR35 GPR37 HTR2C HTR4 JSRP1 PGRMC2 SLC22A1 TMEM242
Entrez ID		51196	27069
HPRD ID		07087	17038
Ensembl ID		ENSG00000138193	ENSG00000165678
Uniprot IDs		B7ZM61 Q9P212	Q9H3K2
PDB IDs		2BYE 2BYF 2C5L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?