CRBN and SLC16A1

Data Source:
BioGRID (pull down, pull down)

		CRBN	SLC16A1
Description		cereblon	solute carrier family 16 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Cul4A-RING E3 Ubiquitin Ligase Complex	Centrosome Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Intracellular Membrane-bounded Organelle Synapse Extracellular Exosome
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Mevalonate Transmembrane Transporter Activity Symporter Activity Identical Protein Binding Carboxylic Acid Transmembrane Transporter Activity Organic Cyclic Compound Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Pyruvate Metabolic Process Lipid Metabolic Process Centrosome Cycle Monocarboxylic Acid Transport Mevalonate Transport Response To Food Plasma Membrane Lactate Transport Glucose Homeostasis Regulation Of Insulin Secretion Leukocyte Migration Behavioral Response To Nutrient Cellular Response To Organic Cyclic Compound Transport Across Blood-brain Barrier Carboxylic Acid Transmembrane Transport
Pathways		Potential therapeutics for SARS	Basigin interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Pyruvate metabolism
Drugs		Lenalidomide Thalidomide Pomalidomide	Pyruvic acid Mersalyl
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 29403010 27863252) White matter integrity ( 23218918)	Macular thickness ( 30535121) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278)
Interacting Genes		36 interacting genes: APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 EGR1 EGR4 GLUL GRB2 GSPT1 GZF1 HIC1 HIC2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 RBPMS RBX1 SALL1 SALL3 SALL4 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 WIZ ZBTB7A ZBTB7B ZFP91	3 interacting genes: AGTR1 BSG CRBN
Entrez ID		51185	6566
HPRD ID		16750	02816
Ensembl ID		ENSG00000113851	ENSG00000155380
Uniprot IDs		Q96SW2	A0A024R0H1 B4DKS0 P53985
PDB IDs		4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 7BQU 7BQV
Enriched GO Terms of Interacting Partners?
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