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CRBN and OSR1
Data Source:
BioGRID
(pull down)
CRBN
OSR1
Description
cereblon
odd-skipped related transcription factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Membrane
Cul4A-RING E3 Ubiquitin Ligase Complex
Chromatin
Nucleus
Cytosol
Extrinsic Component Of Membrane
Molecular Function
Protein Binding
Metal Ion Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Urogenital System Development
Ureteric Bud Development
Mesonephros Development
Chondrocyte Differentiation
Regulation Of Transcription By RNA Polymerase II
Heart Development
Gonad Development
Embryo Development
Positive Regulation Of Gene Expression
Cell Differentiation
Positive Regulation Of Bone Mineralization
Negative Regulation Of Epithelial Cell Differentiation
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Embryonic Skeletal Limb Joint Morphogenesis
Middle Ear Morphogenesis
Odontogenesis
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Intermediate Mesoderm Development
Pronephros Development
Stem Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Roof Of Mouth Development
Embryonic Skeletal Joint Morphogenesis
Cellular Response To Retinoic Acid
Metanephric Mesenchyme Development
Cell Proliferation Involved In Kidney Development
Metanephric Mesenchyme Morphogenesis
Mesangial Cell Development
Metanephric Mesenchymal Cell Differentiation
Posterior Mesonephric Tubule Development
Specification Of Anterior Mesonephric Tubule Identity
Specification Of Posterior Mesonephric Tubule Identity
Mesonephric Duct Morphogenesis
Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation
Renal Vesicle Progenitor Cell Differentiation
Ureter Urothelium Development
Metanephric Epithelium Development
Metanephric Smooth Muscle Tissue Development
Metanephric Nephron Tubule Development
Metanephric Glomerulus Vasculature Development
Metanephric Interstitial Fibroblast Development
Pattern Specification Involved In Metanephros Development
Embryonic Skeletal Joint Development
Metanephric Cap Mesenchymal Cell Proliferation Involved In Metanephros Development
Negative Regulation Of Creatine Transmembrane Transporter Activity
Positive Regulation Of Gastrulation
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Potential therapeutics for SARS
Drugs
Lenalidomide
Thalidomide
Pomalidomide
Diseases
Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Knee osteoarthritis (
27696742
)
Malaria (
31844061
)
Restless legs syndrome (
29029846
)
White blood cell count (basophil) (
29403010
27863252
)
White matter integrity (
23218918
)
Childhood ear infection (
27182965
28928442
)
Coronary artery disease (
32469254
30104761
33020668
)
Facial morphology (
29921221
)
Monobrow (
27182965
)
Pulse pressure (
26390057
27841878
28739976
)
Systolic blood pressure (
27841878
)
Interacting Genes
36 interacting genes:
APPL2
BCL6
BCL6B
BSG
CSNK1A1
CYP19A1
EGR1
EGR4
GLUL
GRB2
GSPT1
GZF1
HIC1
HIC2
IKZF3
KDM1A
KPNB1
MISP
OSR1
OSR2
PAK5
PIK3R3
RBPMS
RBX1
SALL1
SALL3
SALL4
SLC16A1
SQSTM1
SUV39H1
TP53
UBE2D1
WIZ
ZBTB7A
ZBTB7B
ZFP91
3 interacting genes:
CRBN
TGFBR1
TGFBR2
Entrez ID
51185
130497
HPRD ID
16750
16401
Ensembl ID
ENSG00000113851
ENSG00000143867
Uniprot IDs
Q96SW2
Q8TAX0
PDB IDs
4M91
4TZ4
5FQD
5HXB
5V3O
6BN7
6BN8
6BN9
6BNB
6BOY
6H0F
6H0G
6UML
7BQU
7BQV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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