TRAPPC12 and LIN7B

Data Source:
BioGRID (two hybrid)

		TRAPPC12	LIN7B
Description		trafficking protein particle complex subunit 12	lin-7 homolog B, crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding	Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Metaphase Plate Congression Regulation Of Kinetochore Assembly Positive Regulation Of Protein Localization To Kinetochore	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		RAB GEFs exchange GTP for GDP on RABs	Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Serum immune biomarker levels ( 32066700)
Interacting Genes		13 interacting genes: ARNTL FBXO7 HNRNPA2B1 LIN7B MTDH RSKR TFCP2 TRAPPC10 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9	22 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP2 MPP3 MPP7 NTAQ1 PALS1 PALS2 PSMB1 TCEANC TRAPPC12
Entrez ID		51112	64130
HPRD ID		15580	10040
Ensembl ID		ENSG00000171853	ENSG00000104863
Uniprot IDs		A0A0J9YXQ9 Q8WVT3	Q9HAP6
PDB IDs			2DKR
Enriched GO Terms of Interacting Partners?
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