PCMT1 and CHD3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PCMT1	CHD3
Description		protein-L-isoaspartate (D-aspartate) O-methyltransferase	chromodomain helicase DNA binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex PML Body Centriolar Satellite
	Molecular Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding Cadherin Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Double-stranded DNA Helicase Activity Nucleosome-dependent ATPase Activity
	Biological Process	Protein Methylation Protein Repair	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spindle Organization Centrosome Cycle DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Protein repair	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)
Interacting Genes		12 interacting genes: AGTR1 APOA1 APOE CCR2 CHD3 CLP1 CREBBP CYSLTR2 IQCB1 RPIA TAAR1 VKORC1	96 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN ENTR1 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B H3C1 HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1
Entrez ID		5110	1107
HPRD ID		08908	09071
Ensembl ID		ENSG00000120265	ENSG00000170004
Uniprot IDs		A0A0A0MRJ6 A0A3F2YNX8 B7Z972 F6S8N6 P22061	B3KWV4 Q12873 Q2TAZ1
PDB IDs		1I1N 1KR5
Enriched GO Terms of Interacting Partners?
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