SERPINA5 and FBLN5

Data Source:
BioGRID (affinity chromatography technology)

		SERPINA5	FBLN5
Description		serpin family A member 5	fibulin 5
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Collagen-containing Extracellular Matrix Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Seminal Vesicle Development	Cell-matrix Adhesion Extracellular Matrix Organization Protein Localization To Cell Surface Secretion Elastic Fiber Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Urokinase Drotrecogin alfa Tifuvirtide PPL-100
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Blood protein levels ( 30072576 29875488 28240269) Serum albumin level ( 29403010) Serum total protein level ( 29403010)	Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD	12 interacting genes: ATN1 GFI1B LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13
Entrez ID		5104	10516
HPRD ID		03503	05204
Ensembl ID		ENSG00000188488	ENSG00000140092
Uniprot IDs		A0A024R6N9 B4DDH1 P05154	A0A024R6G3 Q9UBX5
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
Enriched GO Terms of Interacting Partners?
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