GLRX2 and DENND1B

Data Source:
BioGRID (affinity chromatography technology)

		GLRX2	DENND1B
Description		glutaredoxin 2	DENN domain containing 1B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body Intracellular Membrane-bounded Organelle	Cytosol Nuclear Speck Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Regulation Of Transcription, DNA-templated Glutathione Metabolic Process Apoptotic Process Aging Response To Temperature Stimulus Regulation Of Signal Transduction Response To Organic Substance Protein Phosphopantetheinylation Electron Transport Chain Cell Differentiation DNA Protection Response To Hydrogen Peroxide Cell Redox Homeostasis Response To Redox State Cellular Response To Superoxide	Endocytosis Protein Transport Endocytic Recycling T-helper 2 Cell Cytokine Production Positive Regulation Of GTPase Activity Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs		Glutathione
Diseases
GWAS		Blood protein levels ( 29875488)	Asthma ( 20032318) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coffee consumption (cups per day) ( 31837886) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Depression ( 29700475) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 21399635 26394269) Primary biliary cirrhosis ( 22961000) Serum protein levels (sST2) ( 23999434) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547)
Interacting Genes		4 interacting genes: DCXR ELF5 FBXO7 TXNRD1	1 interacting genes: LNX1
Entrez ID		51022	163486
HPRD ID		12112	13303
Ensembl ID		ENSG00000023572	ENSG00000213047
Uniprot IDs		Q9NS18	A0A024R987 Q6P3S1
PDB IDs		2CQ9 2FLS 2HT9	3TW8
Enriched GO Terms of Interacting Partners?
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