ISOC1 and MARK2

Data Source:
BioGRID (affinity chromatography technology)

		ISOC1	MARK2
Description		isochorismatase domain containing 1	microtubule affinity regulating kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle
	Molecular Function	Molecular_function Protein Binding	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Biological_process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Waist-to-hip ratio adjusted for BMI ( 28552196)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		1 interacting genes: CALCOCO1	32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ
Entrez ID		51015	2011
HPRD ID		13030	02753
Ensembl ID		ENSG00000066583	ENSG00000072518
Uniprot IDs		Q96CN7	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs			3IEC 5EAK 5KZ7 5KZ8
Enriched GO Terms of Interacting Partners?
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