ARHGEF3 and RHOB

Data Source:
HPRD (in vivo)

		ARHGEF3	RHOB
Description		Rho guanine nucleotide exchange factor 3	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	GPVI-mediated activation cascade Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs			Botulinum toxin type A
Diseases
GWAS		Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Blood protein levels ( 28240269) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 22139419 24026423 19110211 19820697 31194788 32888494 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 26805783 22139419 24026423 29066854 23263863 29403010 32888494 27863252 28031487) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27	12 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 TNFAIP1
Entrez ID		50650	388
HPRD ID		12480	01321
Ensembl ID		ENSG00000163947	ENSG00000143878
Uniprot IDs		B7Z6B2 E9PG37 Q9NR81	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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