ATP6V0A4 and PFKM

Data Source:
HPRD (in vitro, in vivo)

		ATP6V0A4	PFKM
Description		ATPase H+ transporting V0 subunit a4	phosphofructokinase, muscle
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Integral Component Of Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Brush Border Membrane Apical Part Of Cell Extracellular Exosome	Nucleus Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	6-phosphofructokinase Activity Protein Binding ATP Binding Protein C-terminus Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Ossification Regulation Of PH Vacuolar Acidification Excretion Sensory Perception Of Sound Insulin Receptor Signaling Pathway Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport	Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport	Glycolysis
Drugs		Tiludronic acid
Diseases		Distal renal tubular acidosis (RTA type 1)	Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		F-cell distribution in sickle cell anaemia ( 21326311) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)	Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Longevity (90 years and older) ( 25199915) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		2 interacting genes: CYTH2 PFKM	19 interacting genes: ATP6V0A4 CAV3 DLC1 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PDGFRL PFKL SFRP2 SFRP4 SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		50617	5213
HPRD ID		05576	01988
Ensembl ID		ENSG00000105929	ENSG00000152556
Uniprot IDs		A0A024R791 Q9HBG4	A0A024R0Y5 A0A2R8Y891 P08237
PDB IDs			4OMT
Enriched GO Terms of Interacting Partners?
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