OPA1 and BNIP3

Data Source:
BioGRID (two hybrid, pull down)

		OPA1	BNIP3
Description		OPA1 mitochondrial dynamin like GTPase	BCL2 interacting protein 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane Integral Component Of Membrane Mitochondrial Crista Dendrite Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane Axon Cytoplasm	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Postsynaptic Density Dendrite Integral Component Of Mitochondrial Outer Membrane Mitochondrial Membrane
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Kinase Binding Protein-containing Complex Binding Phosphatidic Acid Binding Cardiolipin Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Mitochondrial Genome Maintenance Mitochondrial Fission Neural Tube Closure Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Apoptotic Process Mitochondrion Organization Inner Mitochondrial Membrane Organization Visual Perception Mitochondrial Fusion Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Neuron Maturation Response To Muscle Activity Axonal Transport Of Mitochondrion Response To Nutrient Levels Calcium Import Into The Mitochondrion Negative Regulation Of Apoptotic Process GTP Metabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Intracellular Distribution Of Mitochondria Protein Complex Oligomerization Response To Electrical Stimulus Retina Development In Camera-type Eye Positive Regulation Of Dendritic Spine Morphogenesis Membrane Fusion Mitochondrion Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Cochlea Development Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Senescence Membrane Tubulation Positive Regulation Of Dendrite Development Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Curcumin Cellular Response To L-glutamate	Autophagy Of Mitochondrion Response To Hypoxia Apoptotic Process Cell Death Response To Bacterium Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Necrotic Cell Death Viral Process Positive Regulation Of Macroautophagy Cerebral Cortex Development Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Response To Axon Injury Oligodendrocyte Differentiation Brown Fat Cell Differentiation Neuron Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Defense Response To Virus Response To Hyperoxia Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Oxygen-glucose Deprivation Mitochondrial Outer Membrane Permeabilization Granzyme-mediated Programmed Cell Death Signaling Pathway Toxin Transport Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Regulation of Apoptosis
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy
GWAS		Alcoholic chronic pancreatitis ( 28754779) Brain volume in infants (grey matter) ( 28763065) Dentures ( 31235808) Diastolic blood pressure ( 28270201) Major depressive disorder ( 27479909) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Psychological distress ( 30705256)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: APP BNIP3	70 interacting genes: AGTR1 AMIGO1 ARL13B BCL2 BCL2L1 BCL2L2 BIK BNIP2 BNIP3L CD3E CD47 CLDN9 CLEC7A CLN8 CMTM5 CREB3 CREB3L1 EBAG9 EBP ELOVL4 ERGIC3 FAM209A FAM241B FATE1 FFAR2 FXYD6-FXYD2 GPR152 GPR37 GPR42 HIF1A HIVEP1 HPN HTR2B IFNGR2 JAGN1 KTN1 LDLRAD1 LMNA MALL MAP1LC3B MFSD14B MS4A3 NCBP1 OPA1 PLP2 PPTC7 REEP2 RHEB RNASEK RNF24 RPRM SCN3B SEC22A SEC23A SLC31A2 SLC35B1 SLC6A17 SMIM3 SPACA1 TGM2 TLCD4 TM4SF18 TMEM101 TMEM106C TMEM11 TMEM205 TMPRSS2 TMX2 TNMD ZDHHC15
Entrez ID		4976	664
HPRD ID		05596	04482
Ensembl ID		ENSG00000198836	ENSG00000176171
Uniprot IDs		E5KLJ9 E5KLK0 O60313	Q12983 Q6NVY4
PDB IDs		6JTG	2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?
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