OPA1

Description		OPA1 mitochondrial dynamin like GTPase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Membrane Integral Component Of Membrane Mitochondrial Crista Dendrite Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane Axon Cytoplasm
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Kinase Binding Protein-containing Complex Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Mitochondrial Genome Maintenance Mitochondrial Fission Neural Tube Closure Dynamin Family Protein Polymerization Involved In Mitochondrial Fission Apoptotic Process Mitochondrion Organization Inner Mitochondrial Membrane Organization Visual Perception Mitochondrial Fusion Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Neuron Maturation Response To Muscle Activity Axonal Transport Of Mitochondrion Response To Nutrient Levels Calcium Import Into The Mitochondrion Negative Regulation Of Apoptotic Process GTP Metabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Intracellular Distribution Of Mitochondria Protein Complex Oligomerization Response To Electrical Stimulus Retina Development In Camera-type Eye Positive Regulation Of Dendritic Spine Morphogenesis Membrane Fusion Mitochondrion Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Hypoxia Cochlea Development Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Senescence Membrane Tubulation Positive Regulation Of Dendrite Development Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Curcumin Cellular Response To L-glutamate
Pathways		Regulation of Apoptosis
Drugs
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy
GWAS		Alcoholic chronic pancreatitis ( 28754779) Brain volume in infants (grey matter) ( 28763065) Dentures ( 31235808) Diastolic blood pressure ( 28270201) Major depressive disorder ( 27479909) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Psychological distress ( 30705256)
Interacting Genes		2 interacting genes: APP BNIP3
Entrez ID		4976
HPRD ID		05596
Ensembl ID		ENSG00000198836
Uniprot IDs		E5KLJ9 E5KLK0 O60313
PDB IDs		6JTG
Enriched GO Terms of Interacting Partners?
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