ROR1 and ILKAP

Data Source:
BioGRID (two hybrid)

		ROR1	ILKAP
Description		receptor tyrosine kinase like orphan receptor 1	ILK associated serine/threonine phosphatase
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Axon Terminus	Nucleus Nucleoplasm Cytosol
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Sensory Perception Of Sound Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Inner Ear Development Positive Regulation Of NF-kappaB Transcription Factor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of ERK1 And ERK2 Cascade	Protein Dephosphorylation
Pathways		WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Pancreatic cancer ( 26098869) Severe bacterial meningitis ( 31092817) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 27863252)
Interacting Genes		13 interacting genes: APP DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 ILKAP MFHAS1 PPM1B PPM1F PTPN6 PTPRR STYX	22 interacting genes: AATK CHEK1 EGFR EPHA2 EPHA3 ERBB2 ERBB3 ERBB4 FBXO7 HGS IGF1R ILK KDR KIT LMTK2 MAPK14 MUSK PTK7 ROR1 ROR2 RPS6KA3 TEK
Entrez ID		4919	80895
HPRD ID		03821	17147
Ensembl ID		ENSG00000185483	ENSG00000132323
Uniprot IDs		Q01973	Q9H0C8
PDB IDs		5Z55 6BA5 6BAN 6TU9
Enriched GO Terms of Interacting Partners?
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