ILKAP and MUSK

Data Source:
BioGRID (two hybrid)

		ILKAP	MUSK
Description		ILK associated serine/threonine phosphatase	muscle associated receptor tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Integral Component Of Plasma Membrane Neuromuscular Junction Receptor Complex Postsynaptic Membrane
	Molecular Function	Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Protein Dephosphorylation	Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Protein Autophosphorylation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation
Pathways			ECM proteoglycans
Drugs			Fostamatinib
Diseases			Congenital myasthenic syndrome
GWAS		Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 27863252)	Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		22 interacting genes: AATK CHEK1 EGFR EPHA2 EPHA3 ERBB2 ERBB3 ERBB4 FBXO7 HGS IGF1R ILK KDR KIT LMTK2 MAPK14 MUSK PTK7 ROR1 ROR2 RPS6KA3 TEK	7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1
Entrez ID		80895	4593
HPRD ID		17147	03190
Ensembl ID		ENSG00000132323	ENSG00000030304
Uniprot IDs		Q9H0C8	A0A087WSY1 O15146
PDB IDs
Enriched GO Terms of Interacting Partners?
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