NOVA1 and SMARCC2

Data Source:
HPRD (two hybrid)

		NOVA1	SMARCC2
Description		NOVA alternative splicing regulator 1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Intracellular Membrane-bounded Organelle Synapse	Chromatin Nucleoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing Chemical Synaptic Transmission Locomotory Behavior RNA Splicing Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Cold-induced Thermogenesis	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways			RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophilic esophagitis ( 25407941) Hand grip strength ( 29691431) Metabolite levels ( 23823483) Migraine ( 27182965) Neuritic plaque ( 31497858) Overweight status ( 25133637) Peanut allergy ( 29030101) Plasma anti-thyroid peroxidase levels ( 29678681) Zinc levels ( 26025379)	Asthma ( 31619474) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: APP PCBP1 RPP14 SMARCC2 SRPK1	26 interacting genes: ARRB2 ATXN1 ATXN1L BAZ1B CSNK2A1 EWSR1 FUS GATA1 IFTAP ITCH ITSN1 KLF1 KRT27 MCPH1 NOVA1 PEX14 PHYHIP POLR2C RAB1B RELB SMARCB1 SP1 SRGAP3 TAF15 TERF1 TERF2IP
Entrez ID		4857	6601
HPRD ID		03693	03437
Ensembl ID		ENSG00000139910	ENSG00000139613
Uniprot IDs		B7Z770 P51513	A0A024RB22 F8VXC8 Q8TAQ2
PDB IDs		1DT4 2ANN 2ANR	6KAG 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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