NOP2 and VPS52

Data Source:
BioGRID (two hybrid)

		NOP2	VPS52
Description		NOP2 nucleolar protein	VPS52 subunit of GARP complex
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	GARP Complex Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome EARP Complex
	Molecular Function	RNA Binding Protein Binding RRNA (cytosine-C5-)-methyltransferase Activity	Protein Binding Syntaxin Binding
	Biological Process	Ribosomal Large Subunit Assembly Maturation Of LSU-rRNA RNA Methylation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation RRNA Base Methylation Regulation Of Signal Transduction By P53 Class Mediator	Golgi To Vacuole Transport Lysosomal Transport Ectodermal Cell Differentiation Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Embryonic Ectodermal Digestive Tract Development
Pathways		rRNA modification in the nucleus and cytosol TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971)
Interacting Genes		11 interacting genes: CDC42 CDCA7L CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ SUMO2 UBE2I VPS52	104 interacting genes: AAMP ARNT2 ATP6V1D BORCS6 BYSL C1orf109 C1orf216 C2CD6 CABP5 CACNA1A CCDC102B CCDC13 CCDC146 CCDC185 CCDC187 CCDC33 CCDC57 CCHCR1 CDC20B CDC5L CDK18 CEP19 CFAP206 CWF19L2 DCX DDX6 DNAJC11 DTNB EEF1AKNMT EPM2AIP1 FAM110A FAM161A FAM161B FAM184A FAM50B GEM GFM2 GOLGA1 GORASP2 GPKOW HAUS1 HDAC4 HEATR1 HGS HOXB5 JAKMIP2 KANK2 KIAA1217 KIF5B KIF9 KIFC3 KLC3 KLHL42 LMO4 LNX1 MAGEL2 MAPK3 MFAP1 MRPL1 MRPL11 NDC80 NFKBIB NOP2 NR2C2AP OTUD6A PIMREG PKN3 PPP1R18 PRKAA1 PRKAA2 RAB4A RAB4B RABEP2 RNF41 RUNX1T1 SCNM1 SH2D4A SMARCE1 STX11 TAB2 TBC1D1 TBC1D22B TCEANC TCP11L1 TEAD4 THAP11 TPM3 TRAF4 TRAF6 TSSK3 TSTD2 TXLNA TXLNB TXN2 USP2 VEZF1 VPS28 VPS53 WASHC3 WTAP ZC2HC1C ZMAT2 ZNF417 ZNF587
Entrez ID		4839	6293
HPRD ID		01244	09142
Ensembl ID		ENSG00000111641	ENSG00000223501
Uniprot IDs		P46087	A0A1U9X8S4 B3KMF7 B4DS44 Q4VXZ2 Q8N1B4
PDB IDs
Enriched GO Terms of Interacting Partners?
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