NOP2 and NPM1

Data Source:
HPRD (in vitro)

		NOP2	NPM1
Description		NOP2 nucleolar protein	nucleophosmin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding RRNA (cytosine-C5-)-methyltransferase Activity	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Tat Protein Binding Activating Transcription Factor Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding
	Biological Process	Ribosomal Large Subunit Assembly Maturation Of LSU-rRNA RNA Methylation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation RRNA Base Methylation Regulation Of Signal Transduction By P53 Class Mediator	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Repair Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II RRNA Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Cell Aging Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Cellular Response To UV Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		rRNA modification in the nucleus and cytosol TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs			Artenimol
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: CDC42 CDCA7L CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ SUMO2 UBE2I VPS52	62 interacting genes: ABCC1 ACY1 ALK APP ARF1 CACYBP CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 FBXW7 GADD45A GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 TRIM28 UBC UQCRH XPO1 YY1
Entrez ID		4839	4869
HPRD ID		01244	01246
Ensembl ID		ENSG00000111641	ENSG00000181163
Uniprot IDs		P46087	A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 P06748
PDB IDs			2LLH 2P1B 2VXD 5EHD
Enriched GO Terms of Interacting Partners?
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