SNU13 and RAD17

Data Source:
HPRD (in vivo, two hybrid)

		SNU13	RAD17
Description		small nuclear ribonucleoprotein 13	RAD17 checkpoint clamp loader component
Image			No pdb structure
GO Annotations	Cellular Component	Dense Fibrillar Component Nucleus Nucleoplasm U4atac SnRNP Nucleolus Box C/D RNP Complex Small-subunit Processome Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding U4 SnRNA Binding U4atac SnRNA Binding U3 SnoRNA Binding Box C/D RNA Binding ATPase Binding	Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of LSU-rRNA RRNA Processing Maturation Of SSU-rRNA	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Regulation Of Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs		(S)-3-phenyllactic acid Anisomycin
Diseases
GWAS			Blood urea nitrogen levels ( 31152163)
Interacting Genes		16 interacting genes: CDKN2C CHST1 GTF3C1 HSPB2 LRIF1 MAP1LC3B NUFIP1 POLA2 PPIH RAD17 RBM10 RHOU SMN1 SMN2 SNW1 XRCC6	15 interacting genes: ATM ATR HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20
Entrez ID		4809	5884
HPRD ID		03197	09124
Ensembl ID		ENSG00000100138	ENSG00000152942
Uniprot IDs		P55769 Q6FHM6	O75943
PDB IDs		1E7K 2JNB 2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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