NEUROD1 and TCF12

Data Source:
BioGRID (two hybrid)

		NEUROD1	TCF12
Description		neuronal differentiation 1	transcription factor 12
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Nucleocytoplasmic Transport Nitric Oxide Mediated Signal Transduction Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Neuron Differentiation Endocrine Pancreas Development Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Response To Drug Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Morphogenesis Neuron Development Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494 27863252) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)
Interacting Genes		15 interacting genes: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 NR0B2 PDX1 PITX1 RREB1 TCF12 TCF3 TCF4	76 interacting genes: ARL16 ARMC8 ASCL3 ASCL4 BMERB1 BMF C1orf109 CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FERD3L FIGLA FRMD6 GRB7 HAND1 HAND2 HEXIM2 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC MSGN1 MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NEUROG3 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 WTAP ZNF688
Entrez ID		4760	6938
HPRD ID		03428	02725
Ensembl ID		ENSG00000162992	ENSG00000140262
Uniprot IDs		A0A0S2Z493 Q13562	A0A024R5T1 A0A024R5Z0 F5GY10 Q99081
PDB IDs			2KNH 4JOL
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?