NEUROD1 and RREB1

Data Source:
HPRD (in vitro)

		NEUROD1	RREB1
Description		neuronal differentiation 1	ras responsive element binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Fibrillar Center Nucleus Cytoplasm Nuclear Body Nuclear Speck Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Nucleocytoplasmic Transport Nitric Oxide Mediated Signal Transduction Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Neuron Differentiation Endocrine Pancreas Development Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Response To Drug Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Morphogenesis Neuron Development Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ras Protein Signal Transduction Multicellular Organism Development Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138)	Age-related macular degeneration ( 20385826) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Blood glucose levels ( 31928498) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 29124443) Chronic lymphocytic leukemia or multiple sclerosis ( 31407831) Chronic obstructive pulmonary disease ( 30804561) Estimated glomerular filtration rate ( 31152163 31451708 29124443) Ewing sarcoma ( 30093639) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hyperuricemia ( 29124443) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494 27863252) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 21833088) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Offspring birth weight ( 31043758) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum uric acid levels ( 30993211 29124443) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Triglyceride levels ( 32203549) Type 2 diabetes ( 24509480 30054458 30297969 29632382 32499647 30718926) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31985003 20884846 31578528 23263486) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Visceral adipose tissue adjusted for BMI ( 22589738 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Waist-hip ratio ( 23966867) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 32888494 27863252)
Interacting Genes		15 interacting genes: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 NR0B2 PDX1 PITX1 RREB1 TCF12 TCF3 TCF4	3 interacting genes: H3-4 NEUROD1 SUMO2
Entrez ID		4760	6239
HPRD ID		03428	03733
Ensembl ID		ENSG00000162992	ENSG00000124782
Uniprot IDs		A0A0S2Z493 Q13562	A0A024QZU8 Q92766
PDB IDs
Enriched GO Terms of Interacting Partners?
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