RERE and TRIM22

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RERE	TRIM22
Description		arginine-glutamic acid dipeptide repeats	tripartite motif containing 22
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	RNA Polymerase II Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Remodeling Cerebellar Purkinje Cell Layer Maturation Cerebellar Granule Cell Precursor Proliferation Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Branching Morphogenesis Of A Nerve Dendrite Morphogenesis	Protein Polyubiquitination Regulation Of Transcription, DNA-templated Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Viral Process Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31361310 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Autoimmune thyroid disease ( 32581359) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Diastolic blood pressure ( 27841878) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Feeling miserable ( 29500382) Femoral neck bone mineral density ( 22504420) Fish- and plant-related diet ( 32066663) Heel bone mineral density ( 30598549 28869591) Hippocampal volume in normal cognition ( 29274321) Loneliness ( 31518406) Lymphocyte counts ( 32888494 27863252) Major depressive disorder ( 27479909) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Optic cup area ( 25631615 28073927) Parkinson's disease ( 32201043) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656 30285260) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33536424) Systolic blood pressure ( 30578418) Tonsillectomy ( 27182965 28928442) Total body bone mineral density ( 29304378) Upper eyelid morphology ( 29921221) Vertical cup-disc ratio ( 20548946 25241763) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494 27863252)	Coronary artery disease ( 29212778) Malaria ( 31844061)
Interacting Genes		24 interacting genes: ALG13 ATN1 CBFA2T2 CCDC120 ECM1 EFEMP1 EFEMP2 EHMT2 H3C14 KAT6A KRTAP12-4 KRTAP4-12 KRTAP6-2 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 SNRPC TRIM22 TRIP6 ZMYND8	11 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RERE TAF7 USP7 ZZZ3
Entrez ID		473	10346
HPRD ID		05566	05951
Ensembl ID		ENSG00000142599	ENSG00000132274
Uniprot IDs		Q9P2R6	B4DQS5 Q8IYM9
PDB IDs		2YQK
Enriched GO Terms of Interacting Partners?
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