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NDN and NGFR
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo, in vitro, two hybrid)
NDN
NGFR
Description
necdin, MAGE family member
nerve growth factor receptor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Centrosome
Cytosol
Protein-containing Complex
Cell Projection
Perikaryon
Extracellular Region
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cell Surface
Postsynaptic Density
Integral Component Of Membrane
Growth Cone
Dendritic Spine
Perikaryon
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Gamma-tubulin Binding
Promoter-specific Chromatin Binding
Amyloid-beta Binding
Transmembrane Signaling Receptor Activity
Death Receptor Activity
Protein Binding
Calmodulin Binding
Coreceptor Activity
Small GTPase Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Neurotrophin Binding
Nerve Growth Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Neuron Migration
Respiratory System Process
Axonal Fasciculation
Central Nervous System Development
Negative Regulation Of Cell Population Proliferation
Glial Cell Migration
Post-embryonic Development
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Regulation Of Growth
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Neurotrophin TRK Receptor Signaling Pathway
Axon Extension
Multicellular Organismal Homeostasis
Genetic Imprinting
Positive Regulation Of Protein Deacetylation
Cellular Glucose Homeostasis
Intracellular Protein Transport
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Rho Protein Signal Transduction
Axon Guidance
Central Nervous System Development
Detection Of Temperature Stimulus
Nerve Development
Hair Follicle Morphogenesis
Membrane Protein Intracellular Domain Proteolysis
Circadian Regulation Of Gene Expression
Dorsal Aorta Development
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of Axonogenesis
Positive Regulation Of Axonogenesis
Neuron Apoptotic Process
Negative Regulation Of Hair Follicle Development
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Cellular Response To Amyloid-beta
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Interleukin-4 and Interleukin-13 signaling
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
Regulated proteolysis of p75NTR
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
Drugs
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS
Body size at age 10 (
32376654
)
Depressive symptoms (SSRI exposure interaction) (
25649181
)
HDL cholesterol levels (
32203549
)
Plasma anti-thyroid peroxidase levels (
29678681
)
Serum metabolite concentrations in chronic kidney disease (
29545352
)
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Lower body strength (
27325353
)
Mean spheric corpuscular volume (
32888494
)
Prostate cancer (
23535732
)
Interacting Genes
47 interacting genes:
APBB1IP
ARSL
BLOC1S6
CALCOCO2
CCDC136
CDR2
DTNBP1
E2F1
E2F4
EEF1AKMT1
EGFR
EID1
EPAS1
FAM131C
FSD2
FXR2
GKAP1
GOLGA2
HIF1A
HNRNPU
IFFO1
IL1A
IL32
IRS4
LAX1
LPXN
MIER2
MKRN2
MYG1
NEFL
NGFR
NUBP1
NUCB1
NUCB2
P4HA3
PALS2
PJA1
PPARGC1A
PPFIA1
SERTAD3
SIRT1
SSX2IP
TFIP11
TP53
U2AF1
ZBTB1
ZBTB7B
48 interacting genes:
ANXA7
BEX1
BEX3
BNIP3L
CAV1
CD80
CDKN1A
FSCN1
GRB2
H2AX
IL2
KIDINS220
LINGO1
MAG
MAGED1
MAGEH1
MAPK1
MAPK3
MDM2
NDN
NFKBIB
NGF
NSMCE3
NTF4
NTRK1
NTRK2
NTRK3
PRKACB
PTPN13
RCC1
RIPK2
RPN2
RTN4R
SHC1
SMN1
SORT1
STMN2
TK1
TP53
TRA2B
TRADD
TRAF2
TRAF4
TRAF6
TRIM37
TTR
UFD1
ZNF274
Entrez ID
4692
4804
HPRD ID
03667
01197
Ensembl ID
ENSG00000182636
ENSG00000064300
Uniprot IDs
Q99608
X5D982
P08138
PDB IDs
2N80
2N83
2N97
3EWV
5ZGG
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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