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ATF3 and FGFR3
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ATF3
FGFR3
Description
activating transcription factor 3
fibroblast growth factor receptor 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
CHOP-ATF3 Complex
Extracellular Region
Nucleus
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Transport Vesicle
Receptor Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Fibroblast Growth Factor Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Gluconeogenesis
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Population Proliferation
Cellular Response To Amino Acid Starvation
Skeletal Muscle Cell Differentiation
PERK-mediated Unfolded Protein Response
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Arsenic-containing Substance
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
MAPK Cascade
Skeletal System Development
Endochondral Ossification
Chondrocyte Differentiation
Endochondral Bone Growth
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Peptidyl-tyrosine Phosphorylation
Bone Mineralization
Positive Regulation Of Kinase Activity
Chondrocyte Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Protein Autophosphorylation
Negative Regulation Of Developmental Growth
Positive Regulation Of Protein Kinase B Signaling
Bone Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Bone Maturation
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Signaling by activated point mutants of FGFR3
FGFR3 mutant receptor activation
t(4;14) translocations of FGFR3
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
Drugs
Pseudoephedrine
XL999
Pazopanib
Ponatinib
Lenvatinib
Nintedanib
Fostamatinib
Erdafitinib
Pemigatinib
Selpercatinib
Diseases
Bladder cancer
Multiple myeloma
Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN)
CATSHL syndrome
GWAS
Blood cell traits (multivariate analysis) (
31080455
)
Cerebral amyloid deposition (PET imaging) (
26252872
)
Coronary artery disease (
29212778
)
Thiopurine-induced leukopenia in inflammatory bowel disease (conditioned on rs116855232) (
29923122
)
Bladder cancer (
24163127
20972438
)
Blood protein levels (
30072576
)
Metabolite levels (
23823483
)
Urinary bladder cancer (
20348956
)
Interacting Genes
46 interacting genes:
APPL2
ATF2
ATF4
BATF
BATF3
CEBPA
CEBPE
CEBPG
CREB3
CREBBP
CRK
DBP
DDIT3
DNMT3L
DOK5
FGFR3
FOS
FOSL1
HDAC1
HDAC3
HDAC4
HDAC5
HDAC6
ID3
IGSF21
JUN
JUND
KAT5
LRIF1
MAFF
MAFG
NFKB1
NUF2
PDX1
POLR3D
SH2D1A
SMAD3
SRA1
SS18L1
STAT1
STAT3
SUV39H1
TP53
TP73
UBE2I
ZNF212
43 interacting genes:
ANOS1
ARAP1
ATF3
BORA
C6orf47
CCDC17
CEP126
CHGB
CTSK
EPHA4
ERBB2
FGF1
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GPSM3
GRB2
GTF3C1
HBZ
HNRNPL
KRT8
NDUFS6
NECTIN1
POLA2
PTK2B
RADIL
RNF130
RPL8
RPS6KA3
SH2B1
SLC25A6
SMG7
SRPK2
STAT1
STAT3
Entrez ID
467
2261
HPRD ID
04395
00624
Ensembl ID
ENSG00000162772
ENSG00000068078
Uniprot IDs
P18847
P22607
Q0IJ44
PDB IDs
1RY7
2LZL
4K33
6LVM
6PNX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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