NAGA and GNGT1

Data Source:
HPRD (in vitro)

		NAGA	GNGT1
Description		alpha-N-acetylgalactosaminidase	G protein subunit gamma transducin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Extracellular Exosome	Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane G-protein Beta/gamma-subunit Complex Photoreceptor Disc Membrane
	Molecular Function	Alpha-galactosidase Activity Alpha-N-acetylgalactosaminidase Activity Protein Homodimerization Activity	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Oligosaccharide Metabolic Process Carbohydrate Catabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process Glycosylceramide Catabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Localization Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Eye Photoreceptor Cell Development Cellular Response To Hypoxia
Pathways			Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Glycerin
Diseases		Alpha-N-acetylgalactosaminidase deficiency, including: Schindler disease; Kanzaki disease
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Breast size ( 22747683) Intelligence ( 28530673) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Body mass index ( 28552196) Body size at age 10 ( 32376654) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mosquito bite size ( 28199695) Resting heart rate ( 29769521 27798624) Taxane-induced peripheral neuropathy in breast cancer ( 29278617)
Interacting Genes		2 interacting genes: APP GNGT1	14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277
Entrez ID		4668	2792
HPRD ID		00076	01805
Ensembl ID		ENSG00000198951	ENSG00000127928
Uniprot IDs		A0A024R1Q5 P17050	P63211
PDB IDs		3H53 3H54 3H55 3IGU 4DO4 4DO5 4DO6
Enriched GO Terms of Interacting Partners?
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