GNGT1 and NAGA

Data Source:
HPRD (in vitro)

		GNGT1	NAGA
Description		G protein subunit gamma transducin 1	alpha-N-acetylgalactosaminidase
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane G-protein Beta/gamma-subunit Complex Photoreceptor Disc Membrane	Cytoplasm Lysosome Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Alpha-galactosidase Activity Alpha-N-acetylgalactosaminidase Activity Protein Homodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Localization Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Eye Photoreceptor Cell Development Cellular Response To Hypoxia	Oligosaccharide Metabolic Process Carbohydrate Catabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process Glycosylceramide Catabolic Process
Pathways		Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Glycerin
Diseases			Alpha-N-acetylgalactosaminidase deficiency, including: Schindler disease; Kanzaki disease
GWAS		Body mass index ( 28552196) Body size at age 10 ( 32376654) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mosquito bite size ( 28199695) Resting heart rate ( 29769521 27798624) Taxane-induced peripheral neuropathy in breast cancer ( 29278617)	Autism spectrum disorder or schizophrenia ( 28540026) Breast size ( 22747683) Intelligence ( 28530673) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277	2 interacting genes: APP GNGT1
Entrez ID		2792	4668
HPRD ID		01805	00076
Ensembl ID		ENSG00000127928	ENSG00000198951
Uniprot IDs		P63211	A0A024R1Q5 P17050
PDB IDs			3H53 3H54 3H55 3IGU 4DO4 4DO5 4DO6
Enriched GO Terms of Interacting Partners?
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