MYO9B and RAB8A

Data Source:
BioGRID (proximity labelling technology)

		MYO9B	RAB8A
Description		myosin IXB	RAB8A, member RAS oncogene family
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Endosome Centrosome Centriole Cytosol Plasma Membrane Cilium Synaptic Vesicle Postsynaptic Density Trans-Golgi Network Transport Vesicle Midbody Phagocytic Vesicle Membrane Trans-Golgi Network Membrane Neuronal Cell Body Dendritic Spine Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome Non-motile Cilium Glutamatergic Synapse
	Molecular Function	Microfilament Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding ATPase Activity Small GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding
	Biological Process	Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Vesicle Docking Involved In Exocytosis Autophagy Axonogenesis Protein Secretion Regulation Of Autophagy Regulation Of Exocytosis Cellular Response To Insulin Stimulus Post-translational Protein Modification Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation SLIT2:ROBO1 increases RHOA activity FCGR3A-mediated phagocytosis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Asthma ( 32296059) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 27841878) Glycated hemoglobin levels ( 24647736 28898252) Height ( 20881960 31562340 29782485) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Prostate cancer (early onset) ( 29892016) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Selective IgA deficiency ( 27723758) Systolic blood pressure ( 27841878 30578418) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Waist-to-hip ratio adjusted for BMI ( 28552196)	Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		6 interacting genes: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2	23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC
Entrez ID		4650	4218
HPRD ID		03677	01296
Ensembl ID		ENSG00000099331	ENSG00000167461
Uniprot IDs		B0I1T6 Q13459 Q4LE74 Q8WVD2	A0A024R7I3 P61006
PDB IDs		5C5S 5HPY	3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6ZSI 6ZSJ
Enriched GO Terms of Interacting Partners?
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