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TRIM37 and PNKP
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
TRIM37
PNKP
Description
tripartite motif containing 37
polynucleotide kinase 3'-phosphatase
Image
GO Annotations
Cellular Component
Cytoplasm
Peroxisome
Cytosol
Aggresome
ESC/E(Z) Complex
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Mitochondrion
Membrane
Molecular Function
Chromatin Binding
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Endonuclease Activity
Protein Binding
ATP Binding
Purine Nucleotide Binding
Polynucleotide 3'-phosphatase Activity
ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of NF-kappaB Transcription Factor Activity
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Centriole Replication
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Aggresome Assembly
Nucleotide-excision Repair, DNA Damage Removal
DNA-dependent DNA Replication
DNA Repair
Response To Oxidative Stress
Response To Radiation
Negative Regulation Of Protein ADP-ribosylation
Dephosphorylation
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Damage Response, Detection Of DNA Damage
Nucleotide Phosphorylation
Positive Regulation Of Telomerase Activity
Nucleic Acid Phosphodiester Bond Hydrolysis
Polynucleotide 3' Dephosphorylation
Positive Regulation Of Telomere Capping
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases
Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS
Cognitive function (
25644384
)
General cognitive ability (
29844566
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Testicular germ cell tumor (
23666239
)
Interacting Genes
73 interacting genes:
ANKRD11
APEX2
APTX
AQP1
ARNT2
AXIN1
BYSL
CCDC33
CDC20B
CDC7
CDK5RAP2
CDKL3
COPB1
CWF19L2
DDX6
DLGAP5
DTNB
DZIP1L
ELOA
ELOA2
EWSR1
FAM107A
FAM124B
FAM161A
FAM50B
FXR2
H2AC20
H2AC4
IKBKG
KAT5
KIAA0408
KIF9
LTBR
MAGEB18
MCM10
MCRS1
NGFR
NUDT18
PBK
PNKP
PRC1
RASD1
RHPN1
RIBC2
RNF6
RPL9
RXRB
SCNM1
SYTL4
TCEANC
TNFRSF1B
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
UBASH3A
UBB
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2U
ZBTB24
ZMAT2
ZNF329
ZNF417
ZNF587
ZNF655
49 interacting genes:
APP
CACFD1
CAMK2B
CARD10
CCDC14
CCDC43
CISD2
CNTROB
COL17A1
DVL3
FADS6
GAS8
GZMK
IKZF1
KANK2
KDM1A
KLHL12
KRTAP4-12
LMNA
MAGEA11
MCC
MEOX2
MGST2
MSANTD4
MYOZ1
OBI1
PICK1
PNMA5
POLB
PSTPIP1
RPRM
SFT2D1
SMAD5
SNX2
SP4
SUV39H1
SYNGR1
SYNGR3
SYP
TARBP2
TBC1D1
THAP1
TMEM239
TNIP1
TRIM37
XRCC1
XRCC4
ZBTB14
ZNF639
Entrez ID
4591
11284
HPRD ID
05463
09284
Ensembl ID
ENSG00000108395
ENSG00000039650
Uniprot IDs
O94972
Q96T60
PDB IDs
3LRQ
2BRF
2W3O
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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