MT-ND4 and CTCF

Data Source:
BioGRID (two hybrid)

		MT-ND4	CTCF
Description		NADH dehydrogenase subunit 4	CCCTC-binding factor
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GO Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane Respiratory Chain Complex I	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus
	Molecular Function	NADH Dehydrogenase Activity NADH Dehydrogenase (ubiquinone) Activity Ubiquinone Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding
	Biological Process	Response To Hypoxia In Utero Embryonic Development Mitochondrial Electron Transport, NADH To Ubiquinone Aging Aerobic Respiration Electron Transport Coupled Proton Transport Cerebellum Development Mitochondrial Respiratory Chain Complex I Assembly Response To Nicotine Response To Ethanol	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription By RNA Polymerase II Chromosome Segregation Negative Regulation Of Cell Population Proliferation Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Nucleosome Positioning Regulation Of Histone Methylation Regulation Of Histone Acetylation Regulation Of Gene Expression, Epigenetic Regulation Of Molecular Function, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genetic Imprinting
Pathways		Respiratory electron transport Complex I biogenesis	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		NADH
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS			Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: ABHD16A APC ATM CTCF GRB2 LIG4 NKX3-1	21 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 SUZ12 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6
Entrez ID		4538	10664
HPRD ID		08954	05005
Ensembl ID		ENSG00000198886	ENSG00000102974
Uniprot IDs		A0A1X7RBN5 H9EC08 P03905	A0A2R8YFL0 P49711
PDB IDs		5XTC 5XTD 5XTH 5XTI	1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX
Enriched GO Terms of Interacting Partners?
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