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CTCF and CHD8
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
CTCF
CHD8
Description
CCCTC-binding factor
chromodomain helicase DNA binding protein 8
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
Nucleolus
Nucleus
Nucleoplasm
Protein-containing Complex
MLL1 Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Zinc Ion Binding
Chromatin Insulator Sequence Binding
Sequence-specific DNA Binding
P53 Binding
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Beta-catenin Binding
DNA-dependent ATPase Activity
Methylated Histone Binding
Histone Binding
Armadillo Repeat Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Methylation
Regulation Of Gene Expression By Genetic Imprinting
Regulation Of Transcription By RNA Polymerase II
Chromosome Segregation
Negative Regulation Of Cell Population Proliferation
Maintenance Of DNA Methylation
Positive Regulation Of Gene Expression
Nucleosome Positioning
Regulation Of Histone Methylation
Regulation Of Histone Acetylation
Regulation Of Gene Expression, Epigenetic
Regulation Of Molecular Function, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Regulation Of Centromeric Sister Chromatid Cohesion
Protein Localization To Chromosome, Centromeric Region
Genetic Imprinting
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Brain Development
Wnt Signaling Pathway
DNA Duplex Unwinding
Social Behavior
ATP-dependent Chromatin Remodeling
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
Digestive Tract Development
Prepulse Inhibition
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Fibroblast Apoptotic Process
Pathways
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS
Elevated fasting plasma glucose (
30004843
)
Eosinophil percentage of white cells (
32888494
)
HDL cholesterol (
19060911
)
Hemoglobin levels (
32327693
)
Refractive error (
32231278
)
Height (
31562340
)
Interacting Genes
21 interacting genes:
CHD1L
CHD7
CHD8
HMGB1
MT-ND4
PARP1
POLR2A
RAD51
RALA
RHOU
RXRA
SIN3A
SMAD3
SMAD4
SUZ12
THRB
TRAF2
TRB
YBX1
ZMYM4
ZMYM6
11 interacting genes:
AR
ASH2L
CHD7
CREB1
CTCF
CTNNB1
RBBP5
RCHY1
SUMO2
TOP3B
WDR5
Entrez ID
10664
57680
HPRD ID
05005
16712
Ensembl ID
ENSG00000102974
ENSG00000100888
Uniprot IDs
A0A2R8YFL0
P49711
Q9HCK8
PDB IDs
1X6H
2CT1
5K5H
5K5I
5K5J
5K5L
5KKQ
5T00
5T0U
5UND
5YEF
5YEG
5YEH
5YEL
6QNX
2CKA
2DL6
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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