GOLGA6L9 and HDAC4

Data Source:
BioGRID (two hybrid)

		GOLGA6L9	HDAC4
Description		golgin A6 family like 9	histone deacetylase 4
Image		No pdb structure
GO Annotations	Cellular Component		Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Transcription Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin
	Molecular Function	Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Development Chromatin Remodeling Protein Deacetylation Inflammatory Response Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Smooth Muscle Cell Migration Histone Deacetylation Protein Sumoylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of DNA-binding Transcription Factor Activity Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of Male Mating Behavior Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX2 regulates chondrocyte maturation RUNX3 regulates p14-ARF
Drugs			Zinc Belinostat Romidepsin Panobinostat N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		Tourette syndrome ( 30818990)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Body size at age 10 ( 32376654) Chronotype ( 30696823) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Diastolic blood pressure ( 30224653 30487518) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Heel bone mineral density ( 30598549) Intra-individual response time variability (selective attention) ( 30287865) Male-pattern baldness ( 22693459) Mean arterial pressure ( 29403010 30487518) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30487518)
Interacting Genes		215 interacting genes: ANKRD11 ARHGAP9 ASXL1 ATP6V1G1 ATPAF2 ATXN7L2 AVPI1 BAG6 BAHD1 BANP BCL6B BHLHA9 BYSL C1orf109 C1orf35 C22orf15 C3 CABP2 CATIP CAVIN3 CBX8 CCDC116 CCDC120 CCDC146 CCDC185 CCDC187 CCHCR1 CDC37 CDC73 CDK18 CEP72 CEP95 CNNM3 CWF19L2 DAXX DEF6 DENND5A DES DOCK2 DPF2 DUSP26 EAF1 EIF3D ENKD1 FAAP20 FAM107A FAM110A FAM161A FAM161B FAM207A FBXO28 FEM1A FLYWCH1 FXN GADD45GIP1 GAS2L2 GEM GLIS2 GPANK1 GTF2B HAPLN2 HBZ HDAC4 HDAC7 HGS HOXB5 HOXB9 HOXC8 IL16 INO80B ISCU JMY JRK KANK2 KCTD9 KLHL35 KRT1 KRT75 LAGE3 LENG1 LGALS4 LMO3 LMO4 LYSMD1 M1AP MAB21L2 MBD3 MBD3L2 MFAP1 MOS MRPL11 MYOZ3 NAB2 NDUFAF3 NSMF NTAQ1 NXF1 NXT2 ORC1 PATZ1 PCDHB14 PHF1 PIN1 PKN1 PNMA5 POLL POLR1C POU6F2 PPP1R18 PRKAB2 PRPF18 PRPF31 PWWP2B RANBP3L RASSF10 RIN1 RLN1 RNF39 RNPS1 RTP5 SCAND1 SCNM1 SH2D4A SHC3 SLIRP SMARCD1 SMARCE1 SNAI1 SSX5 STAMBPL1 STK25 SUOX SUV39H1 SUV39H2 TACO1 TBC1D30 TCEANC TEAD4 THAP7 TJAP1 TLE5 TLX3 TMSB4X TPRX1 TRAF3IP3 TRAF4 TRIM14 TSEN54 TSFM TSGA10IP TSPYL4 TTC23 TXN2 TYK2 UBASH3A UBL4B UBTFL1 USHBP1 USP2 VEZF1 WDR25 ZBTB16 ZBTB24 ZFHX3 ZFP1 ZGPAT ZKSCAN3 ZMAT2 ZNF124 ZNF155 ZNF165 ZNF17 ZNF20 ZNF205 ZNF230 ZNF250 ZNF264 ZNF32 ZNF329 ZNF35 ZNF410 ZNF414 ZNF417 ZNF438 ZNF444 ZNF446 ZNF479 ZNF48 ZNF490 ZNF497 ZNF524 ZNF552 ZNF557 ZNF574 ZNF578 ZNF580 ZNF581 ZNF587 ZNF599 ZNF624 ZNF628 ZNF629 ZNF648 ZNF669 ZNF696 ZNF764 ZNF785 ZNF792 ZNF80 ZNF835 ZNF837 ZNF844 ZNHIT1 ZSCAN23 ZSCAN26	123 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ASB15 ATF3 ATRX BCL6 BCOR BEGAIN BICD2 BLZF1 BORCS8-MEF2B BRMS1 CACNA1C CADPS CALCOCO2 CAMK4 CBX5 CCDC125 CCDC136 CCNDBP1 CDKN1A CDPF1 CDR2 CDR2L CEBPD CEP70 CIITA CSRP3 CTBP1 DYDC1 EFEMP2 EFHC2 ESR1 FCHSD2 FSD2 GATA1 GCM1 GOLGA2 GOLGA6L9 GRIPAP1 GSK3B HAP1 HDAC3 HDAC7 HDAC9 HNF4A HOOK2 HSF2BP IFRD1 IKZF2 INCA1 JDP2 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MID2 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBID NFKBIE NPPB NR1H2 NR2C1 NR2C2 PICK1 PNMA1 PPARD PPARG PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SSX2IP SUMO1 SUMO2 SYK TFIP11 TLE5 TNFRSF14 TRIB3 TRIM27 TSGA10 UBE2I VPS52 YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZMYND12 ZNF354A
Entrez ID		440295	9759
HPRD ID			05610
Ensembl ID		ENSG00000197978	ENSG00000068024
Uniprot IDs		A6NEM1	P56524
PDB IDs			2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ
Enriched GO Terms of Interacting Partners?
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