MPZ and RGS4

Data Source:
BioGRID (proximity labelling technology)

		MPZ	RGS4
Description		myelin protein zero	regulator of G protein signaling 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Myelin Sheath Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Structural Molecule Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding
	Biological Process	Chemical Synaptic Transmission Myelination Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Aggregation	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Hip circumference adjusted for BMI ( 28552196) Visceral adipose tissue adjusted for BMI ( 22589738)	Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		3 interacting genes: PINX1 PMP22 PSMB3	13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR
Entrez ID		4359	5999
HPRD ID		01159	03947
Ensembl ID		ENSG00000158887	ENSG00000117152
Uniprot IDs		A0A5F9ZI26 P25189	A0A024R909 P49798
PDB IDs		1N2P 3OAI
Enriched GO Terms of Interacting Partners?
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