MPL and ANKRA2

Data Source:
BioGRID (unspecified method)

		MPL	ANKRA2
Description		MPL proto-oncogene, thrombopoietin receptor	ankyrin repeat family A member 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Membrane Neuron Projection Neuronal Cell Body	Nucleus Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex
	Molecular Function	Protein Binding Thrombopoietin Receptor Activity	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Neutrophil Homeostasis Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Platelet Aggregation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly
Pathways		Platelet Aggregation (Plug Formation)
Drugs		Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases		Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Monobrow thickness ( 26926045)
Interacting Genes		9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ	13 interacting genes: ABL1 APP CDKN2A HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3
Entrez ID		4352	57763
HPRD ID		01161	12044
Ensembl ID		ENSG00000117400	ENSG00000164331
Uniprot IDs		P40238	A0A024RAN7 Q9H9E1
PDB IDs			3SO8 3V2O 3V2X 3V31 4LG6 4QQI
Enriched GO Terms of Interacting Partners?
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