MMP16 and PIP4P2

Data Source:
BioGRID (proximity labelling technology)

		MMP16	PIP4P2
Description		matrix metallopeptidase 16	phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Matrix	Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Late Endosome Membrane
	Molecular Function	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Metalloaminopeptidase Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity
	Biological Process	Skeletal System Development Endochondral Ossification Proteolysis Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Chondrocyte Proliferation Embryonic Cranial Skeleton Morphogenesis Regulation Of Catalytic Activity Craniofacial Suture Morphogenesis	Phosphatidylinositol Dephosphorylation Negative Regulation Of Phagocytosis
Pathways		Activation of Matrix Metalloproteinases
Drugs		Marimastat Batimastat
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 31043756) Body mass index and cholesterol (psychopharmacological treatment) ( 22417934) Cerebral amyloid deposition (PET imaging) ( 26252872) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Heel bone mineral density ( 30598549) Irritable mood ( 29500382) Migraine without aura ( 23793025) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Sweet taste perception in obesity with metabolic syndrome ( 31005965)
Interacting Genes		2 interacting genes: KISS1 LRP1	5 interacting genes: GTF2IRD1 NEDD4L SLC10A6 TNF ZFYVE27
Entrez ID		4325	55529
HPRD ID		03776	13233
Ensembl ID		ENSG00000156103	ENSG00000155099
Uniprot IDs		P51512	Q8N4L2
PDB IDs		1RM8
Enriched GO Terms of Interacting Partners?
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