MLF1 and COP1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MLF1	COP1
Description		myeloid leukemia factor 1	COP1 E3 ubiquitin ligase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cilium Ciliary Basal Body	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Protein Binding Protein Domain Specific Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Arrest	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways			Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Major depressive disorder ( 27479909) PR interval ( 32439900) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 30224653)
Interacting Genes		9 interacting genes: CENPU COP1 COPS3 DNAJB6 GRIK5 MAGEA11 MEOX2 NRBP1 YWHAZ	19 interacting genes: CCT4 CDKN1B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ
Entrez ID		4291	64326
HPRD ID		03239	07455
Ensembl ID		ENSG00000178053	ENSG00000143207
Uniprot IDs		A0A0S2Z4U8 A0A140VKD2 B2RD48 P58340 Q2TLE4 Q5HYH4	Q8NHY2 X5D7N8 X5DNY7
PDB IDs		3UAL 3UBW	5HQG 5IGQ
Enriched GO Terms of Interacting Partners?
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