CIITA and TAF9

Data Source:
BioGRID (pull down)

		CIITA	TAF9
Description		class II major histocompatibility complex transactivator	TATA-box binding protein associated factor 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol PML Body	SAGA Complex PCAF Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex STAGA Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Transferase Activity, Transferring Acyl Groups Activating Transcription Factor Binding Protein-containing Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transcription Regulatory Region Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Activating Transcription Factor Binding Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Immune Response Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Viral Entry Into Host Cell Response To Antibiotic Interferon-gamma-mediated Signaling Pathway	Box C/D SnoRNP Assembly Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process SnRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Interferon gamma signaling	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases		Bare lymphocyte syndrome (BLS) type2 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 20190752) Monocyte percentage of white cells ( 32888494) Nasopharyngeal carcinoma ( 27436580) Systemic lupus erythematosus ( 27399966 26502338) Ulcerative colitis ( 20228799)
Interacting Genes		17 interacting genes: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1
Entrez ID		4261	6880
HPRD ID		02475	15983
Ensembl ID		ENSG00000179583	ENSG00000273841
Uniprot IDs		A0A087X2I7 A0A0B4J1S1 P33076 Q66X48	Q16594
PDB IDs			6F3T 6MZC 6MZD 6MZL 6MZM
Enriched GO Terms of Interacting Partners?
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