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SMCP and GRN
Data Source:
BioGRID
(two hybrid)
SMCP
GRN
Description
sperm mitochondria associated cysteine rich protein
granulin precursor
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Membrane
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Azurophil Granule Lumen
Extracellular Exosome
Molecular Function
Molecular_function
Protein Binding
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Chaperone Binding
Biological Process
Penetration Of Zona Pellucida
Flagellated Sperm Motility
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Neutrophil Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Axon Regeneration
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Aspartic-type Peptidase Activity
Positive Regulation Of Lysosome Organization
Pathways
Neutrophil degranulation
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Blood protein levels (
30072576
29875488
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Interacting Genes
75 interacting genes:
ALPP
C14orf119
CALCOCO2
CGB3
CGB5
CGB8
CTAG2
CYSRT1
DYNLL1
DYNLL2
GOLGA2
GRN
GUCD1
IGFBP6
KRT31
KRT34
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-4
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2C
LCE2D
LCE3A
LCE3B
LCE4A
LCE5A
MACO1
MT1B
MT1M
NBPF19
NOTCH2NLA
PCSK5
PLEKHG4
PLSCR1
PLSCR3
PPP1R27
PRDX5
RGS17
SLC39A7
SPRY1
TCF4
TRIM42
UBL5
VASN
79 interacting genes:
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
MEOX2
NLK
NUFIP2
OTX1
P4HB
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SLC13A1
SLPI
SMAD9
SMCP
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
Entrez ID
4184
2896
HPRD ID
03093
00733
Ensembl ID
ENSG00000163206
ENSG00000030582
Uniprot IDs
P49901
Q5T7P5
P28799
PDB IDs
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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