MARK1 and KCNK2

Data Source:
BioGRID (proximity labelling technology)

		MARK1	KCNK2
Description		microtubule affinity regulating kinase 1	potassium two pore domain channel subfamily K member 2
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Apical Plasma Membrane Neuronal Cell Body Calyx Of Held Astrocyte Projection
	Molecular Function	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization	Cardiac Ventricle Development G Protein-coupled Receptor Signaling Pathway Memory Response To Mechanical Stimulus Positive Regulation Of Cell Death Stabilization Of Membrane Potential Response To Axon Injury Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Hypoxia Potassium Ion Transmembrane Transport Cochlea Development Positive Regulation Of Cellular Response To Hypoxia Negative Regulation Of DNA Biosynthetic Process
Pathways			TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
Drugs		Fostamatinib	Dofetilide Dronedarone
Diseases
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Lung function (FVC) ( 30061609) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2
Entrez ID		4139	3776
HPRD ID		07353	04450
Ensembl ID		ENSG00000116141	ENSG00000082482
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	O95069 Q6ZW95 U3N6F0 U3N834
PDB IDs		2HAK 3OSE 6C9D	4TWK
Enriched GO Terms of Interacting Partners?
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