ASIC1 and ASIC2

Data Source:
HPRD (in vitro, in vivo)

		ASIC1	ASIC2
Description		acid sensing ion channel subunit 1	acid sensing ion channel subunit 2
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Synapse	Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Dendritic Spine
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity Acid-sensing Ion Channel Activity	Protein Binding Ligand-gated Sodium Channel Activity Ion Gated Channel Activity
	Biological Process	Behavioral Fear Response Response To Amphetamine Sodium Ion Transport Signal Transduction Memory Associative Learning Response To PH Response To Acidic PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neurotransmitter Secretion Sensory Perception Of Sour Taste Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To PH	Regulation Of Systemic Arterial Blood Pressure By Aortic Arch Baroreceptor Feedback Chemical Synaptic Transmission Central Nervous System Development Peripheral Nervous System Development Phototransduction Sensory Perception Of Sound Response To Acidic PH Regulation Of Vasoconstriction Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Protein Localization To Synapse Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Apoptotic Process Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Involved In Sensory Perception Positive Regulation Of Synapse Assembly Inorganic Cation Transmembrane Transport
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs		Amiloride	Amiloride
Diseases
GWAS			Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 26912274) Mosquito bite size ( 28199695) Plasma parathyroid hormone levels ( 30134803) Polycystic ovary syndrome ( 30343302) Serum bilirubin levels in metabolic syndrome ( 30621171) Severe gingival inflammation ( 28459102)
Interacting Genes		7 interacting genes: ASIC2 ATXN3 KIR3DL3 MGST2 PICK1 PRKACA STOM	4 interacting genes: ASIC1 ASIC3 PICK1 STOM
Entrez ID		41	40
HPRD ID		04182	03471
Ensembl ID		ENSG00000110881	ENSG00000108684
Uniprot IDs		A8K1U5 P78348	Q16515
PDB IDs		6L6I 7CFS 7CFT	6L6P
Enriched GO Terms of Interacting Partners?
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