MAG and COL3A1

Data Source:
HPRD (in vitro)

		MAG	COL3A1
Description		myelin associated glycoprotein	collagen type III alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Paranode Region Of Axon Myelin Sheath Adaxonal Region Myelin Sheath Compact Myelin Schmidt-Lanterman Incisure Membrane Raft Mesaxon	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Protein Kinase Binding Carbohydrate Binding Sialic Acid Binding Protein Homodimerization Activity Ganglioside GT1b Binding	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Cell Adhesion Negative Regulation Of Neuron Projection Development Transmission Of Nerve Impulse Central Nervous System Myelination Negative Regulation Of Axon Extension Axon Regeneration Positive Regulation Of Myelination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Axonogenesis Leukocyte Migration Cellular Response To Mechanical Stimulus Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Skeletal System Development Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Skin Development Regulation Of Immune Response Negative Regulation Of Immune Response Supramolecular Fiber Organization Negative Regulation Of Neuron Migration
Pathways		Axonal growth inhibition (RHOA activation) Basigin interactions EGR2 and SOX10-mediated initiation of Schwann cell myelination	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs			Collagenase clostridium histolyticum
Diseases			Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: APP COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL9A1 COL9A2 COL9A3 FN1 FYN MAP1B MBP NGFR PLP1 PRNP RTN4R	14 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF
Entrez ID		4099	1281
HPRD ID		01160	00365
Ensembl ID		ENSG00000105695	ENSG00000168542
Uniprot IDs		P20916 Q53ES7	P02461
PDB IDs			2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW
Enriched GO Terms of Interacting Partners?
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